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[1] These are meaningful cosmetic endpoints, and they map logically onto the mechanism: more collagen and glycosaminoglycan synthesis, better-organized remodeling, and reduced oxidative and inflammatory burden should, in principle, translate into firmer, smoother, more resilient skin

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In the SURMOUNT trials for tirzepatide, researchers used an escalation starting at 2.5 mg weekly, increasing by 2.5 mg every four weeks until reaching the target maintenance dose (typically 5 mg, 10 mg, or 15 mg)

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